Topiramate for Migraine Prevention<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
نویسندگان
چکیده
منابع مشابه
Topiramate for migraine prevention: a randomized controlled trial.
CONTEXT Small open-label and controlled trials suggest that the antiepileptic drug topiramate is effective for migraine prevention. OBJECTIVE To assess the efficacy and safety of topiramate for migraine prevention in a large controlled trial. DESIGN, SETTING, AND PATIENTS A 26-week, randomized, double-blind, placebo-controlled study was conducted during outpatient treatment at 52 North Amer...
متن کاملEfficacy of Topiramate in Migraine Prophylaxis: a Randomized Controlled Study*
Topiramate has been under investigation for the past several years as a prophylactic agent for migraine and other headache disorders. Studies to date have shown it to be safe and effective. As with other antiepileptic drugs, its exact mechanisms of action are not yet known, or at least, the mechanisms that are important in its efficacy in migraine are not yet defined. Topiramate acts on several...
متن کاملTopiramate for migraine prophylaxis.
Topiramate is a neurmodulatory compound with neuron stabilizing properties and is approved for the preventive treatment of migraine in several countries [5]. Several small and large trials have reported good efficacy and safety of topiramate in migraine prophylaxis in adults [6]. The present study was done to study the role of topiramate in migraine prophylaxis in children who either failed to ...
متن کاملTopiramate as Migraine Prophylaxis in Pediatric Patients: An Integrated Summary of Randomized Controlled Trials
Background: An integrated analysis of five randomized, placebo-controlled studies in migraine prophylaxis was conducted to assess topiramate’s efficacy and safety in pediatric patients. Methods: Study 1, a pivotal study (50-, 100 mg/day; aged 12-17 years), Study 2 (flexibly-dosed 2-3 mg/kg/day; aged 6-15 years), and Studies 3, 4 and 5 [50-, 100-, 200 mg/day; aged ≥ 12 years)]. Results: Percent ...
متن کاملRandomized, placebo-controlled trial of propranolol added to topiramate in chronic migraine.
OBJECTIVE To assess the efficacy and safety of adding propranolol to topiramate in chronic migraine subjects inadequately controlled with topiramate alone. METHODS This was a double-blind, placebo-controlled, randomized clinical trial conducted through the National Institute of Neurological Disorders and Stroke Clinical Research Collaboration, expected to randomize 250 chronic migraine subjec...
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ژورنال
عنوان ژورنال: JAMA
سال: 2004
ISSN: 0098-7484
DOI: 10.1001/jama.291.8.965